Histomorphometrical evaluation of the gastrointestinal mucosa following chronic administration of Ghrelin in rat

نویسندگان

  • Arash Kheradmand گروه پاتوبیولوژی، دانشکده دامپزشکی دانشگاه لرستان، خرم آباد
  • Farzam Sheikhzadeh گروه زیست شناسی جانوری، دانشکده علوم طبیعی دانشگاه تبریز، تبریز
  • Majid Taati گروه پاتوبیولوژی، دانشکده دامپزشکی دانشگاه لرستان، خرم آباد
  • Morteza Zendehdel گروه علوم پایه، دانشکده دامپزشکی دانشگاه تهران
  • مرتضی زنده دل گروه زیست شناسی جانوری، دانشکده علوم طبیعی دانشگاه تبریز، تبریز
چکیده مقاله:

Ghrelin, a peptide hormone, has several functions, of which the best known is its growth hormone (GH)-releasing effect in the pituitary. It also increases appetite and feeding behavior. Recent studies have implicated ghrelin in the regulation of gastrointestinal, cardiovascular, and immune function, and suggest a role for ghrelin in bone physiology. In this study, the effect of chronically administered ghrelin on the histomorphometrical properties of stomach and different parts of intestinal mucosa were evaluated in a rat model. Significant differences between control and ghrelin-treated groups were observed in gastrointestinal mucosa, stomach gland length, and duodenal mucosal thickness, villus length and crypt depth (P

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histomorphometrical evaluation of the gastrointestinal mucosa following chronic administration of ghrelin in rat

ghrelin, a peptide hormone, has several functions, of which the best known is its growth hormone (gh)-releasing effect in the pituitary. it also increases appetite and feeding behavior. recent studies have implicated ghrelin in the regulation of gastrointestinal, cardiovascular, and immune function, and suggest a role for ghrelin in bone physiology. in this study, the effect of chronically admi...

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عنوان ژورنال

دوره 5  شماره 3

صفحات  173- 177

تاریخ انتشار 2011-09-01

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